Alzor HCT Dosage/Direction for Use

Adults: The recommended starting dose of Olmesartan Medoxomil and Hydrochlorothiazide combination is 40/12.5mg once daily in patients whose blood pressure is not adequately controlled with Olmesartan monotherapy.
The recommended starting dose of Olmesartan Medoxomil and Hydrochlorothiazide combination is 20/12.5mg once daily in patients whose blood pressure is not adequately controlled with Hydrochlorothiazide monotherapy or who experience dose-limiting adverse reactions with hydrochlorothiazide.
Elderly (age 65 years or over): In elderly people the same dosage of the combination is recommended as for adults.
Renal impairment: When Olmesartan and Hydrochlorothiazide combination is used in patients with mild to moderate renal impairment (creatinine clearance of 30 - 60 mL/min) periodic monitoring of renal function is advised. Olmesartan and Hydrochlorothiazide combination is contraindicated in patients with severe renal impairment (creatinine clearance < 30 mL/min).
Hepatic impairment: Olmesartan and Hydrochlorothiazide combination should be used with caution in patients with mild to moderate hepatic impairment. In patients with moderate hepatic impairment, an initial dose of 10 mg Olmesartan Medoxomil once daily is recommended and the maximum dose should not exceed 20 mg once daily. Close monitoring of blood pressure and renal function is advised in hepatically-impaired patients who are receiving diuretics and/or other antihypertensive agents. There is no experience of Olmesartan Medoxomil in patients with severe hepatic impairment.
Olmesartan and Hydrochlorothiazide combination should not be used in patients with severe hepatic impairment, cholestasis and biliary obstruction.
Pediatric population: The safety and efficacy of Olmesartan and Hydrochlorothiazide in children and adolescents below 18 years has not been established. No data are available.
Method of administration: The tablet should be swallowed with a sufficient amount of fluid (e.g. one glass of water). The tablet should not be chewed and should be taken at the same time each day.